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i.e., liver blood flow decreased by 39% when pneumoperitoneum increased from 10 to 15 mmHg and liver ischemic injury occurred (Chen et al., 2017)

Aging is associated with decreased reduced glutathione in cells and increased oxidized glutathione, indicating a pro-oxidizing shift in redox balance

10.1016/j.ejphar.2013.08.045 92 PeiB.YangM.QiX.ShenX.ChenX.ZhangF

Glutathione synthesis is induced by oxidative stress, which stabilizes nuclear factor erythroid 2related factor 2 (NRF2) to induce the transcription of both GCLC and GCLM and a battery of antioxidant enzymes that detoxify reactive oxygen species (ROS) (Harris and DeNicola, 2020)