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Exclusion criteria for all groups included current or previous psychiatric comorbidities as diagnosed by DSM-5, using a structured interview (The Structured Clinical Interview for DSM-5, SCID-5) [28] if deemed relevant by the investigator, any general medical conditions known to influence energy processing and/or linked to fatigue, current treatment with any medication/supplementation likely to interfere with energy metabolism if deemed relevant by the investigator, contra-indications to magnetic resonance (MR) imaging, pregnancy or breast feeding

Cross-linked bromelain inhibits lipopolysaccharide-induced cytokine production involving cellular signaling suppression in rats

Poor sleep sabotages your bodys production of glutathione, triggers oxidative stress, and leaves your cells vulnerable to damage: a combination that can contribute to chronic fatigue, inflammation, and long-term health issues

Stegenga ME, van der Crabben SN, Blmer RM, Levi M, Meijers JC, Serlie MJ, Tanck MW, Sauerwein HP, van der Poll T