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Deutsches Arzteblatt international, 106(34-35), pp

Giralt M, Gavalda-Navarro A, Villarroya F

By reducing NNMT catalytic activity, the compound allows researchers to evaluate how limiting nicotinamide methylation influences: In vitro and in vivo experimental models (non-clinical, non-human) have demonstrated that NNMT suppression leads to measurable changes in cellular energy markers and adipocyte behavior

GavriatopoulouMKastritisENtanasis-StathopoulosIFotiouDRoussouMMigkouMet al.The addition of IMiDs for patients with daratumumab-refractory multiple myeloma can overcome refractoriness to both agents