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27 , 843853.e846 (2018)

For example, the accepted view is that general control nonderepressible 2 (GCN2) senses decreased tRNA charging after a reduction in hepatic amino acids and initiates the ISR through increased phosphorylation of eukaryotic initiation factor 2 alpha (eIF2) 9,10,11,12,13,14,15,16

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