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In 2015, a Cognitive Vitality Report released by the Alzheimers Drug Discovery Foundation stated that two multi-year treatment trials had found that epithalamin, from which epitalon is isolated, had imparted no severe adverse events in older adults, and that preclinical trials supported a favorable safety profile.35 Ten years later, a systematic review published in 2025 stated that information regarding critical issues about this peptides safety is missing.1 In terms of human trials, the best case we have in support of epitalons safety is a 2002 trial involving 162 patients in which no one in the epitalon group reported serious side effects.36 At the same time, the U.S

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Two other genetic studies revealed a positive association between ASD and other SNPs of MET in the same intron (intron 1), such as rs38845 in Caucasian population patients (Sousa et al., 2009) and rs38841 in Japanese population patients (Thanseem et al., 2010)