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doi: 10.18632/oncotarget.6568 43 WeissWAAldapeKMohapatraGFeuersteinBGBishopJM

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Regular blood monitoring, which is already standard practice for methotrexate users, helps identify any emerging issues with liver function, kidney function, or blood counts that might be influenced by the combination of medications or by inadequate nutrition

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This includes disorganization of the annular lamellae with decreased proteoglycan content, bifurcation, and interdigitation (Lai et al., 2015)

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Although Vitamin B12 supplementation may not reverse existing nerve degeneration, it can stop further damage and improve symptoms

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