monosodium (([5-(1,1-dimethylethyl)thiazol-2-yl]methyl)([(4-(4-[4-(1-propylbutyl)phenoxy]methyl)phenyl)thiazol-2-yl]methyl)amino)acetate, a specific protein tyrosine phosphatase 1B inhibitor in vitro and in vivo, mixed-type inhibition mode versus PTPB1, overview kanjone - karanjin - L-Tartrate - weak licochalcone A - licochalcone E - lithocholic acid - natural inhibitor against PTP1B lobaric acid - a depsidone-type compound, isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum lupenone - isolated from Sorbus commixta stem bark, inhibits PTP1B in a selective and noncompetitive manner lupeol - isolated from Sorbus commixta stem bark, inhibits PTP1B in a selective and noncompetitive manner maslinic acid menadione inhibits Cdc25B irreversibly methyl (4R)-4-[(1R,3aS,3bS,10aR,10bS,12aR)-8-amino-6,6,10a,12a-tetramethyl-2,3,3a,3b,4,6,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[2,3-d][1,3]thiazol-1-yl]pentanoate - - methyl (4R)-4-[(1R,3aS,3bS,11aR,11bS,13aR)-6,6,11a,13a-tetramethyl-2,3,3a,3b,4,6,11,11a,11b,12,13,13a-dodecahydro-1H-cyclopenta[5,6]naphtho[1,2-g]quinoxalin-1-yl]pentanoate - - methyl (4R)-4-[(E)-2-(4-bromophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-4-[(E)-2-(4-bromophenyl)ethenyl]-6-tert-butyl-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-4-[(E)-2-(4-chlorophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate methyl (4R)-4-[(E)-2-(4-fluorophenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate methyl (4R)-4-[(E)-2-(4-methoxyphenyl)ethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-4-[(E)-2-phenylethenyl]-6-(propan-2-yl)-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-6-(propan-2-yl)-2-sulfanylidene-4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-6-tert-butyl-2-sulfanylidene-4-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-6-tert-butyl-4-[(E)-2-(4-chlorophenyl)ethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-6-tert-butyl-4-[(E)-2-(4-fluorophenyl)ethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-6-tert-butyl-4-[(E)-2-(4-methoxyphenyl)ethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-6-tert-butyl-4-[(E)-2-(4-methylphenyl)ethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-6-tert-butyl-4-[(E)-2-(4-nitrophenyl)ethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl (4R)-6-tert-butyl-4-[(E)-2-phenylethenyl]-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carboxylate - methyl 2,4-dihydroxy-6-methylbenzoate - isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum methyl 2-(3-(1-(4-fluorobenzyl)-6-nitro-4-oxo-1,4-dihydroquinoline-3-carboxamido)propoxy)-6-hydroxybenzoate - IC50 of 6.5 mg/ml methyl 2-(3-(1-benzyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamido)propoxy)-6-hydroxybenzoate - IC50 of 9.4 mg/ml methyl 2-[4-[(4-[[ethoxy(oxo)acetyl][2-(methoxycarbonyl)phenyl]amino]-3-ethylphenylalanyl)amino]butoxy]-6-hydroxybenzoate - methyl 3,8-dimethoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylate - isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum methyl 3-formyl-2,4-dihydroxy-6-methylbenzoate - isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum methyl 4,4-dimethyl-3-oxochol-5-en-24-oate - - methyl 5-amino-6-(7-amino-6-methoxy-5,8-dioxo-5,8-dihydroquinolin-2-yl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpyridine-2-carboxylate - methyl 8-hydroxy-3-methoxy-11-oxo-1-pentanoyl-6-pentyl-11H-dibenzo[b,e][1,4]dioxepine-7-carboxylate - isolated from a methanol extract of the Antarctic lichen Stereocaulon alpinum methyl oleanolic acid amide - methyl oleanolic acid ester - methyl phenylcarbamate - methyl-5-((3-(benzylcarbamoyl)-6-iodo-4-oxoquinolin-1(4H)-yl)methyl)-2-methoxybenzoate - IC50 of more than 20 mg/ml Mg2+ - - Mn2+ - - mokko lactone - 93.1% PTP1B inhibitory activity with 0.00141 mg/ml molybdate mpV(pic) - potent and selective PTP inhibitor, inhibits SPH-1 in a dose-dependent manner MSI-1436 small molecule inhibitor MSI-1436 binds to the disordered C-terminal domain of PTP1B, C-terminal to the catalytic domain, MSI-1436 functions using an allosteric mechanism to direct the enzymatic activity of PTP1B N,1-dibenzyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxamide - 41.4% inhibition at 0.02 mg/ml N,1-dibenzyl-6-iodo-4-oxo-1,4-dihydroquinoline-3-carboxamide - 61.8% inhibition at 0.02 mg/ml N,N'-[benzene-1,4-diylbis(propane-2,2-diylbenzene-4,1-diyl)]bis(1,1,1-trifluoromethanesulfonamide) - - N-((4-((E)-2-nitroethenyl)phenyl)carbonyl)glycyl-L-alpha-glutamyl-L-glutamic acid - 50% inhibition at 0.0014 mM in absence of 2-mercaptoethanol, at 0.275 mM in presence of 1 mM 2-mercaptoethanol N-((4-(difluoro(phosphono)methyl)phenyl)acetyl)-L-a-aspartyl-4-(difluoro(phosphono)methyl)-L-phenylalaninamide - inhibition of enzyme increases caveolin-1 phosphorylation N-((4-(difluoro(phosphono)methyl)phenyl)acetyl)-L-alpha-aspartyl-4-(difluoro(phosphono)methyl)-L-phenylalaninamide - - N-(1,3-benzothiazol-2-yl)-2-chloroacetamide modeling of PTP1B bound to the compound N-(1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(4-methylphenyl)acetamide - N-(3-chloro-4-fluorophenyl)-2-[(6,7-dimethoxy-4-oxo-3-phenyl-3,4-dihydro-2-quinazolinyl)sulfanyl]acetamide 80% inhibition at 0.2 mM N-(3-formylphenyl)-3-(((3-((3-formylphenyl)carbamoyl)phenyl)carbamoyl)amino)benzamide - suramin-derivative, 50% inhibition of PTP1B above 0.1 mM, reversible and competitive
Bhandari, N
For others, simply focusing on a diet rich in sulfur and Vitamin C is enough to feel the benefits
Exercise, estrogen, and ischemic cardioprotection by heat shock protein 70
