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Figures 1a, c, d, 3a, 6a, b and 7c, d were created using Biorender for which we own a full licence

NO is primarily synthesized in organisms by nitric oxide synthase (NOS), an enzyme divided into three subtypes: inducible iNOS, endothelial eNOS, and neurogenic nNOS (115)

A recent Phase I clinical trial found administering CuII (atsm) in ALS patients was safe and well-tolerated (Lincoln, 2018)

A recent study found that elevated levels of lactate and cortisol in the peripheral blood of SZ patients were significantly correlated with decreased immune parameters (such as reactive lymphocytes) and altered concentrations of cerebral metabolites like glutamate and N-acetylaspartate (73)