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This method is often used at the start of treatment or for severe symptoms

Our present results indicate that treatment with a heavy-chain anti-CD38 antibody selectively targeting the ectoenzyme domain, but not with an anti-CD38 antibody that does not block ectoenzyme, prevented bleomycin-induced weight loss, skin fibrosis and architectural remodeling in the lung, accompanied by reduced collagen deposition and significant improvement of pulmonary functions

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For weight management concerns, patients should request referral to NHS tiered weight management services, which provide evidence-based, multidisciplinary support