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Under the catalysis of peroxidases (ALOXs), reactive substances interact with polyunsaturated fatty acids (PUFAs) on the membrane of organelles to produce reactive lipids (RLS), such as malondialdehyde (MDA), which in turn activate ferroptosis 31

As shown in Figure 7 , in mock- and GSTP1 -transfected HepG2 cells dose- and time- dependent up-regulations of CHOP-GFP signal were detected following treatment with AQ-QI or DEAQ-QI

Behavioral tests, along with cellular and molecular analyses, confirmed forskolins role in restoring mitochondrial function and repairing neurodegeneration [123]

for example, staying out of the sun or not using some kind of skin cream