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A recent epidemiological study revealed that the worldwide prevalence of FC and IBS-C in adults is 11.7% and 1.3% respectively [2]

Microorganisms, including Escherichia coli or Clostridium species, produce enzymes like beta-glucuronidase, which hydrolyse conjugated bilirubin back into its unconjugated form, increasing the probability of precipitation [27, 35]

The Effects of Choline on Hepatic Lipid Metabolism, Mitochondrial Function and Antioxidative Status in Human Hepatic C3A Cells Exposed to Excessive Energy Substrates