The implication of GST polymorphisms may be significant as studies suggest that that loss of mu, pi and theta GST genes increase susceptibility to inflammatory diseases, and a genetic deficiency of GSTM1 is associated with increased susceptibility to ozone-related asthma [61] and to susceptibility to AFB1-mediated damage to human liver cells [62]
developed galactose-tailored poly (lactide-co-glycolide) (PLGA) nanoparticles loaded with AP (AP-GAL-NPs) for active liver targeting to treat HCC and found that AP-GAL-NPs exhibited a better protective effect against HCC in rats evidenced by the significant reduction of nodule formation, downregulation of MMP-2 and MMP-9, and induction of apoptosis in the liver (Ganguly et al., 2021)
doi: 10.1186/s13048-022-00962-w Summary Keywords neuroexcitotoxicity, ferroptosis, glutamate, cystine-glutamate antiporter, ischemic stroke Citation Fan G, Liu M, Liu J and Huang Y (2023) The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation
in the future, the combination of specific receptor modulators, molecular targeting, and immune regulation is expected to achieve personalized treatment and precise inflammation control
