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These antioxidant effects are thought to be mediated through a dual mechanism: indirectly, by improving systemic metabolism and cardiac energy efficiency (Usman et al., 2024), and more directly, through the inhibition of myocardial NOX2 expression and the activation of endogenous antioxidant pathways such as Nrf2(Preda et al., 2024)

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Characterization of the most frequent ATP7B mutation causing Wilson disease in hepatocytes from patient induced pluripotent stem cells