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To address the limitations of traditional transdermal drug delivery in treating deep cartilage injuries, Lins team developed a solid MN with threaded grooves (ST MN)

As a first attempt, we created NAPstar3b, featuring a single point mutation, V126Y, in the N-terminal NAPstar3-derived Rex domain instead of the usual V130Y mutation which was kept in the second, C-terminal, NAPstar3-derived Rex domain

4.2.1 NF1-associated OPG displays temporal and spatial specificity and is highly dependent on cell-of-origin and MAPK pathway activation The mTOR pathway had been well-implicated in NF1-associated disorders (85, 95, 96), and it was shown that MAPK pathway activation in NF1 -deficient astrocytes resulted from RAS hyperactivation (78, 85)

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