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While there is no definitive evidence proving that glutathione can directly prevent hair loss, its antioxidant properties may help protect hair follicles from oxidative stress, which is linked to hair loss

They observed that CYP1B1-derived metabolites such as 5-Hydroxyeicosatetraenoic acid (5-HETE) and 15-HETE from arachidonic acid increased PPAR transcriptional activity and prevented the Mn-induced downregulation of PPAR and tight junction proteins in hCMEC/D3 cells [141]

Additionally, increased iron storage levels in macrophages are believed to correlate with macrophage polarization, which further influences airway inflammation and the progression of fibrosis [37]