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Binding to antioxidant response elements (AREs) induces the transcription of genes regulated by AREs, which initiates the expression of genes encoding cytoprotective enzymes, such as antioxidative stress proteins, especially antioxidant enzymes ( Figure 2 The antioxidant response is also modulated by signaling pathways mediated by adenosine 5'-monophosphate-activated protein kinase (AMPK)

The epithelial cells reported to have a great metabolic rate and divide rapidly which has been considered to be a potent factor responsible for the oxidation of DNA

CD36 is thought to be involved in the initiation of metastasis [77] and the promotion of fatty acid -oxidation to support proliferation [78]

The liver generally oxidises xenobiotics and produces glucuronic acid, sulfate or glutathione conjugates