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While the Clade 2 GS enzyme tested clearly has a slower rate of canonical enzyme activity than the Clade 1 GS, it can nevertheless synthesise glutathione: It has a high affinity for the -EC dipeptide substrate, and a preference for glycine as the terminal amino acid despite a lack of conservation in the two residues that apparently contribute to this specificity

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Ferroptosis promotes the development of AS through inflammation, endothelial cell dysfunction, and the formation of foam cells, using ferroptosis inhibitors in AS could reverse these effects, which may provide new targets and strategies for the prevention and treatment of AS

Epidemiologic and economic consequences of the global epidemics of obesity and diabetes