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However, in a large study involving people with diabetes who had no comorbidities, GLP-1 RAs were not shown to increase the risk of developing pancreatitis at any time point up through 5 years of use.[ref][ref][ref][ref] The Cleveland Clinic now counsels that GLP-1 RA patients should be screened for pancreatitis risk factors, and a lower dose should be used to reduce the risk of pancreatitis.[ref] Related article : Pancreatitis and Genetic Risk Factors Gastroparesis: Case reports tie semaglutide to a risk of gastroparesis (very slow stomach emptying)

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After sealed and reacted at 60 C in water bath for 90min , it was taken out and diluted with 0.05mol / L acetic acid buffer (pH = 4.0) to scale, and was filtered