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There is also evidence to suggest that the vasoconstrictive effect related to scavenging of NO by the oxygenated heme can be reversed in the presence of glutathione, especially under anaerobic conditions (30)

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Although these studies suggest that expression patterns of GR isoforms contribute to unique cellular responses to glucocorticoids, future in vivo studies of GR mRNA/protein isoform overexpression are required to confirm GR isoform-specific functions