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In critically ill patients, anti-anaerobic antibiotics increase risk of adverse clinical outcomes

doi:10.1007/s12070-019-01655-5

(2019) demonstrated that AS-IV activates the Keap1/Nrf2 antioxidant pathway by downregulating Keap1 expression in the cytoplasm, promoting dissociation of Keap1 from Nrf2, facilitating Nrf2 release and translocation to the nucleus, where it binds Maf to initiate the transcription of the antioxidant gene HO-1