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Low SAM may limit methyl-donor reserve and could interfere with SAM-dependent creatine synthesis

The involvement of mitochondria in Ca 2+ cycling regulation and ATP production makes these organelles crucial for synaptic function during neurodevelopment and in the adult brain

The AUC of low-dose group were higher than other groups from 4 weeks after operation ( P = 0.002) ( P = 0.000) ( P = 0.000) and the AUC of high-dose group had no significant difference with that of the control group at the end of 12 weeks ( P = 0.077)

Acetylation, another critical PM, regulates mTOR-mediated mitochondrial function and cardiomyocyte survival (Table 3) (172)