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The hyperthermic stress response, in particular, is highly conserved and, beyond its role in stress protection, modulates various normal cellular functions (86)

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Other Important Contributors : IFN- (Interferon-gamma) - A variant like +874 T/T can cause macrophages (your body's cleanup cells) to go overboard, leading to excessive activation and the formation of granulomas (clumps of immune cells that wall off threats but can cause damage in diseases like sarcoidosis or tuberculosis)