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Flanagan SV, Johnston RB, Zheng Y (2012) Arsenic in tube well water in Bangladesh: health and economic impacts and implications for arsenic mitigation

This system works via a different set of signaling hormones: Gonadotropin-Releasing Hormone (GnRH) from the hypothalamus stimulates Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) from the pituitary, and it's the LH that directly signals the Leydig cells to synthesize testosterone