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High concentrations of H 2 O 2 in the epidermis are toxic to melanocytes because they inhibit tyrosinase and deactivate catalase

(Laboratory temperature: 20-25, laboratory relative humidity: 20-60%

Hille B, Cartterall WA

By contrast, a porcine enzyme entitled SscGST A2-2, linked to ovarian follicular differentiation and showing 84% sequence identity with the human enzyme, was found to approach the high ketosteroid activity of HsaGST A3-3 ( Based on mutational studies of human GSTs the five H-site residues in positions 10, 12, 111, 208, and 216 were judged to be of particular importance for the ketosteroid isomerase activity (Pettersson et al., 2002)