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This reaction is catalyzed by 5-ALA synthase, located in mitochondria, and is rate limiting in heme synthesis

Cheraghi M, Ahmadvand H, Maleki A, Babaeenezhad E, Shakiba S, Hassanzadeh F

Other than mRNA, lung spheroid cell Exo loaded with protein cargo showed superior biodistribution and retention in the bronchioles and parenchyma following nebulized administration compared with both HEK cell-derived exosomes and liposomes 217