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As uteroplacental circulation becomes established, the oxygen tension increases in the intervillous space, enhancing the trophoblast invasion for further vascular remodeling ( Oxidative Stress in Placental Pathologies When the tight balance between ROS generation and antioxidant generation is interrupted, it can lead to increased generation of chronic oxidative stress leading to inflammatory responses and damage to the cellular system at the DNA and RNA levels ( Fetal growth restriction is the failure of the fetus to reach its genetic growth potential ( Maternal preeclampsia is a life-threatening disorder of pregnancy, characterized by new onset hypertension, proteinuria, abnormal maternal and renal adaptations, poor placenta vascularization and FGR ( Spontaneous pregnancy loss occurs when the initial onset of the blood flow in the intervillous chamber occurs earlier and is less organized than in normal pregnancies leading to an increase in oxidative stress in the placenta ( Gestational Diabetes Mellitus is a serious pregnancy complication, in which women without previously diagnosed diabetes develop chronic hyperglycemia during gestation ( As described above, uteroplacental insufficiency from defective placentation can provoke chronic hypoxia, leading to PE, FGR, neurodevelopmental delay and intrauterine fetal death

doi: 10.7326/AITC201901010 123 SmolenJAletahaDBartonABurmesterGEmeryPFiresteinGet al

Yang C, Wang W, Li S, et al

Datis Kharrazian: Sure, I mean I got into functional medicine because I had a sick family member and they were helped by someone who did nutrition at the time, where functional medicine still wasnt developed as a concept and as an institution