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In chronic pain management, these medications are often used repeatedlysometimes for months or yearswithout fully addressing the underlying cause of inflammation or tissue injury

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Despite the absence of specific protocols for cirrhosis patients, sleep diaries are heralded as the gold standard for subjective sleep assessment ( Objective methods for sleep disorders assessment in cirrhosis include the polysomnography test which stands as the gold standard for diagnosing sleep disturbances, but its practicality is hindered by high costs and patient compliance challenges

These genes had not been regularized by glucocorticoid therapy previously received by the patients before sample collection to this study