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According to the bias assessment using the Cochrane Collaborations risk of bias tool, this study had a lower risk of bias

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Methionine supplementation decreased DNA methylation level and promoted the up-regulation of PPAR target genes angiopoietin like 4 (ANGPTL4), fibroblast growth factor 21 (FGF21), and phosphoenolpyruvate carboxykinase 1 (PCK1) in the liver