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Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission

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doi: 10.1289/ehp.5916 142 JindalSSinghMBalakumarP

Moreover, studies have shown that Nrf2 can not only combine with an ARE between nucleotide positions 608 to 600 to induce the expression of the Bcl-xL gene, but also bound to ARER3 in thepromoter region of the Bcl-2 gene after Nrf2 is transferred to the nucleus, increasing the Bcl-2 gene transcription, thus realizing the direct regulation of apoptosis by Nrf2 ( Figure 4 ) (58, 59)