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Complying with preclinical studies, a single-blind nonrandomized controlled clinical trial on T2D patients given with black cumin seed capsule demonstrated a significant decline in TC, LDL-C, TC/HDL-C, LDL-C/HDL-C ratios, DBP, MAP and HR, and increase of serum HDL-C level [142]

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The mechanism isn't hypothetical

It is also worth emphasizing that ceragenin-induced host cell damage can be controlled by using Pluronic F-127 (Paprocka et al., 2021), which reduces the toxicity of CSA-13 and does not affect its bactericidal activity (Bucki et al., 2015)