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High doses should be tapered gradually to avoid side-effects like raised blood pressure

For instance, lysine 4 of histone H3 and histone H3 lysine 27 trimethylation were found to be enriched in latent HIV-1 chromatin in both microglial cells and CD4 + T cells, suggesting that targeting these epigenetic pathways may suppress HIV-1 latency and microglial activation [184, 185]

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