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Inflammation, steatosis, ballooning, and fibrosis are the features of non-alcoholic fatty liver disease (NAFLD), and the associated critical bona fide genes such as MCP-1, TNF, TNFR1, TGF1, Col1, SMA, Timp1, and Hp were significantly enriched in the livers of mice fed an HFD

Brent R Stockwells group in 2012, who discovered this new cell death pattern that differs from apoptosis, necrosis and autophagy (Kuang et al., 2020)

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For example, a three-month course of lactulose therapy significantly improved sleep quality, reduced daytime sleepiness, and increased sleep duration and REM sleep in patients with minimal HE (31, 33)