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SKU: 1674890376 · From astonvaughan.co.uk

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The underlying mechanism is thought to be closely linked to social jetlag, which describes the misalignment between an individuals endogenous circadian rhythm and externally imposed social schedules (Haraguchi et al., 2021)

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After SCI, resident microglial cells (macrophages) are the first immune cells to react, rapidly switching to an amoeboid, phagocytic state and, together with infiltrating CCR2 + (CC chemokine receptor type 2) blood-borne monocyte-derived macrophages, create an ionized calcium-binding adaptor molecule 1 (Iba1) front that both clears debris and intensifies tissue damage through Tumor Necrosis Factor-alpha (TNF-), Interleukin-1 beta (IL-1), and reactive oxygen species (ROS) (Timofeeva et al., 2025)