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Description

In preclinical studies, cancer cells were dependent on glutamine, and glutaminase inhibition led to reduced cell growth and induced apoptosis [8689]

ABBV-399 targets the SEMA domain of c-MET, blocking HGF binding and inducing receptor internalization, degradation, or cytotoxic effects [10]

65 , 219 , 220 The shared homology and cross-reactivity between gluten peptides and human epitopes reinforce the molecular mimicry pathway toward inflammation and end-organ dysfunction