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Rapid determination of N-acetyl-4-aminophenol (paracetamol) in urine by tandem mass spectrometry coupled with on-line clean-up by two dimensional turbulent flow/reversed phase liquid chromatography

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The following specific directions are proposed to better elucidate the underlying mechanisms and assess potential risks: Conduct large-scale longitudinal cohort studies integrating exposure assessment and neurological outcomes Future research should prioritize prospective cohort studies designed to integrate detailed assessments of individual MPs/NPs exposureusing methods such as environmental monitoring, biomonitoring, and questionnaireswith longitudinal evaluation of PD progression, including relevant biomarkers, neuroimaging, and clinical symptoms