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Pullarkat V, Blanchard S, Tegtmeier B, Dagis A, Patane K, Ito J, et al Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation Bone Marrow Transplant

M1 macrophages substantially depend on glycolytic metabolism, whereas M2 primarily depends on oxidative phosphorylation (Saha et al., 2017)

But for routine wellness, the marginal benefit is uncertain and may not justify the cost and risk

In contrast to the central nervous system (CNS) which is well protected by a bloodbrain barrier, the sensory neurons and axons in the peripheral nervous system (PNS) are more susceptible than the CNS to damage from chemotherapy drugs, due to the absence of an effective blood-nerve barrier in the PNS (Starobova and Vetter, 2017)