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Furthermore, having in mind that microRNA (miRNA)146a may directly induce OPC differentiation to OLs (Zhang et al., 2017a, Liu et al., 2016b), T4 treatment may prominently stimulate the expression of this mRNA in primary cultured OPCs, thus promoting the proliferation and differentiation of OPCs and OLs (Santra et al., 2014), which may serve as a common remyelination therapeutic mechanism