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This post-translational modification is now recognised as a major mechanism of redox-regulated cell signalling, controlling the activity of transcription factors, kinases, phosphatases, and metabolic enzymes in response to the intracellular redox environment

77 Additionally, AARS2 also mediates the lactylation of pyruvate dehydrogenase E1 component subunit alpha (PDHA1) at K336 and carnitine palmitoyltransferase 2 (CPT2) at K457/8, leading to the inactivation of both of these enzymes

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