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doi: 10.1177/0269881115599386 80 KrupaAebkowskaAKondraciukMKaminskiKAKowalskaI

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We demonstrate how endocrine-disrupting chemicals (EDCs) may act as potential triggers for the development of thyroid disease, obesity and diabetes, and how SGLT2 inhibitors may constitute a potential protective barrier against their negative effects

When exposed to ROS, Nrf2 migrates from the cytoplasm to the nucleus where it leads to the upregulation of expression of several antioxidant and detoxification genes (e.g., GSTs, SODs, and HO-1), the downregulation of NF-B, and reduction in proinflammatory cytokines (e.g., IL-6 and IL-1)