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Glutathione neutralizes these free radicals before they harm your cells

J Immunol 164:62876295 Nishiyama A, Matsui M, Iwata S et al (1999) Identification of Thioredoxin-binding Protein-2/Vitamin D3 Up-regulated protein 1 as a negative regulator of thioredoxin function and expression

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Together with previous work showing that perturbations of the N-terminal loop or -SNAP/Sec17 membrane engagement compromise SNARE complex disassembly and membrane fusion dynamics 11,37,38 , these findings support the idea that the M105I mutation may impair membrane fusion not only by diminishing plasma membrane binding, but also by diverting -SNAP into non-productive, off-pathway membrane contacts that cannot support a properly assembled 20S complex