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High levels of NEDDylation pathway enzymes, and consequently NEDDylated proteins, have been observed in both human premalignant (biliary intra-epithelial neoplasia) and malignant tissues, correlating with poor prognosis 151,152

The two main ones are salicylic acid, due to the theoretical risk of salicylate poisoning to the baby, and vitamin A derivatives like retinol and retinoids, due to the risk of teratogenicity to the baby, which can cause defects such as a misshapen head or heart abnormalities, explains dermatologist and founder of Torontos Dermatelier on Avenue, Dr

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