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PDE4B controls 1AR but not 2AR responses in cardiac myocytes, suggesting a localized function to control 1AR-dependent excitationcontraction coupling (Mika et al., 2014)

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Normality and homogeneity of variances were confirmed by the ShapiroWilk and Levene tests, respectively, before parametric analyses (t-test and ANOVA) were run

In hypoxic disc environments, hypoxia-inducible factor 1 alpha (HIF-1) activates autophagy pathways, helping to mitigate ROS generation while promoting chondrogenic differentiation and cartilage matrix synthesis [84]