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In a PCOS model induced by estradiol valerate in mice, EA reversed elevated LH levels, normalized miRNA-21 expression, and restored the number of primordial and Graafian follicles (95, 96)

314 (3), H659H668

For example, recent studies have shown that ER stress within beta cells leads to translational errors in the reading frame of human insulin mRNA, resulting in the generation of defective polypeptides and the formation of neo-epitopes, capable of recognition by circulating T cell populations which have escaped prior thymic deletion (Kracht et al