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Leonard et al., 1993)

Vitamin B12 enables the release of energy by helping the human body absorb folic acid

While targeted therapies have made significant strides in GBM management, their clinical efficacy remains inconsistent due to tumor heterogeneity and acquired resistance

Studies show core biological changes, including reduced NK cell function, activation of the NLRP3 inflammasome, altered interferon and cytokine signaling, and evidence of mitochondrial and metabolic dysfunction (lactate/pyruvate, haptoglobin)