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Spiro-Containing Derivatives Show Antiparasitic Activity against Trypanosoma Brucei through Inhibition of the Trypanothione Reducatase Enzyme

Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors

Simultaneously, there are disruptions in the expression of signaling pathways such as Transforming growth factor- (TGF-) signaling pathways, VEGF/VEGFR signaling pathways, Angiopoietin (Ang)/Tie signaling pathways, among others, ultimately driving glomerular fibrosis and progressing towards end-stage pathological conditions like glomerulosclerosis

Plasticity in the brain refers to the ability to change and adapt as needed