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Radiation-induced downregulation of BACH transcriptional regulator 1 (BACH1), a transcriptional repressor of SLC7A11 , further sensitizes cells to cuproptosis 170

This process consumes significant energy and substances, and the inflammatory mediators entering the circulation act as new signaling molecules, inducing further inflammation throughout the body

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For the 29 genes that were upregulated by TCPOBOP in sham, their LFC was significantly less high in CLP relative to sham ( Figure 1D )