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Description

The cardiovascular system and brain are interconnected through a complex network of bidirectional neural pathways involving multilayered afferent and efferent polysynaptic axonal connections [70]

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Nature Communications , 8 , 14483

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Progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis is marked by a higher frequency of Th17 cells in the liver and an increased Th17/resting regulatory T cell ratio in peripheral blood and in the liver

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However, oxidative stress-mediated changes in cellular machinery allow Nrf2 to escape the degradation pathways and translocate to the nucleus

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