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Researchers continue to investigate these pathways to better understand cellular communication and molecular regulation in laboratory models

While we cannot disregard the possibility of some remaining effects of relaxation time differentials, we note that our results are metabolite-specific, while systematic between-group differences in relaxation times would likely impact all metabolite concentrations equally

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Our findings add to the growing body of research on the role of the brainstem in opioid-induced constipation by revealing a PVN Glu DMV Ach circuit that directly modulates small intestinal function in response to morphine