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MC4-NN20453 entered the clinic in 2010 to investigate safety, tolerability, and pharmacokinetic exposures in overweight and obese participants ( Table 2 ) (57)

More importantly, the interfering peptide, TAT-DAT NT , attenuates hyperactivity and improves spontaneous alternation behavior in spontaneously hypertensive rats (SHR) ------ a common animal model of ADHD