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(90) have uncovered a previously unannotated gene that is induced in 3T3-L1 cells during differentiation into adipocytes

ATP6AP1 associates with the V 0 sector of lysosomal v-ATPase, and its loss impairs lysosomal acidification v-ATPases are present in multiple cellular locations as proton pumps, such as the plasma membrane, Golgi-derived and secretory vesicles, endosomes and lysosomes 27